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The nuclei showed MT asters, including one in apparent metaphase, although oddly, the nuclear material appeared to be at the edge In bed kinda bored lets chat the cell.

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MCF7 cells were untreated A or treated with 1. Changes were apparent at the 1 h time point for cells treated with RPC2 and 30 min for the PTX treated cells with effects for both more pronounced at longer time periods.

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For more information please review our cookie policy. Clearly, the DIP ligand increases the tubulin binding affinity and indicates that SAR studies can improve their performance. Lost in Translation.

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The extent of the photobleaching varied and, in many instances, cells were imaged with little bleaching. Presumably, this is an effect of the relatively short time period after introduction of the drug 3 h compared to a typical MTT assay 96 h.

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For comparison, the IC 50 values for nocodazole and paclitaxel are included in Table 1both show low micromolar to nanomolar cytotoxicity.